RNA sensor-induced type I IFN prevents diabetes caused by a Î2 cell-tropic virus in mice

نویسندگان

  • Stephen A. McCartney
  • William Vermi
  • Silvia Lonardi
  • Cristina Rossini
  • Karel Otero
  • Boris Calderon
  • Susan Gilfillan
  • Michael S. Diamond
  • Emil R. Unanue
  • Marco Colonna
چکیده

"RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice.

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RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice.

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درمان موش‌های دیابتیک نوع 1 با آل- ترانس رتینوئیک اسید از طریق مهار سایتوکاین‌های پیش التهابی

    Background & Aims: Type 1 diabetes is an autoimmune condition associated with the T-cell–mediated destruction of Pancreatic β cells. Vitamin A (retinol) and its metabolites (such as all-trans retinoic acid (ATRA)) have a variety of biological activities including immunomodulatory action in a number of inflammatory and autoimmune conditions. The purpose of this study was to investigate the e...

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Oral administration of self-antigens has been proposed as a therapy to prevent and treat autoimmune diseases. Here we report that oral treatment with insulin prevents virus-induced insulin-dependent diabetes mellitus (IDDM) in a transgenic (tg) mouse model. Such mice express the viral nucleoprotein (NP) of lymphocytic choriomeningitis virus (LCMV) under control of the rat insulin promoter in th...

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تاریخ انتشار 2015